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Related Concept Videos

2D NMR: Overview of Homonuclear Correlation Techniques01:16

2D NMR: Overview of Homonuclear Correlation Techniques

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Homonuclear correlation spectroscopy (COSY) is a powerful technique used in Nuclear Magnetic Resonance (NMR) spectroscopy to study the correlations between nuclei of the same type within a molecule. It provides information about scalar couplings between adjacent nuclei, which helps determine connectivity and structural information. There are several COSY variants, each with its unique strengths and experimental parameters.
COSY90 is the standard two-dimensional (2D) COSY experiment that...
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Chemical Shift: Internal References and Solvent Effects01:17

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In an NMR sample, precise measurement of the absolute absorption frequencies of nuclei is difficult. A standard internal reference compound is added, and the frequency difference between the reference signal and sample signals is measured.
The internal reference compound generally used in NMR spectroscopy is tetramethylsilane (TMS). TMS is preferred because it is chemically inert, soluble in NMR solvents, and easily removable. Also, the highly shielded methyl protons in TMS yield an intense...
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NMR Spectrometers: Resolution and Error Correction01:14

NMR Spectrometers: Resolution and Error Correction

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When magnetic nuclei in a sample achieve resonance and undergo relaxation, the signal detected in NMR is an approximately exponential free induction decay. Fourier transform of an exponential decay yields a Lorentzian peak in the frequency domain. Lorentzian peaks in an NMR spectrum are defined by their amplitude, full width at half maximum, and position, where the peak width is governed by the spin-spin relaxation time alone. In real experiments, however, the applied magnetic field is rendered...
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¹H NMR: Interpreting Distorted and Overlapping Signals01:02

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Spin systems where the difference in chemical shifts of the coupled nuclei is greater than ten times J are called first-order spin systems. These nuclei are weakly coupled, and their chemical shifts and coupling constant can generally be estimated from the well-separated signals in the spectrum.
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2D NMR: Overview of Heteronuclear Correlation Techniques01:18

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Heteronuclear correlation spectroscopy is an analytical technique that investigates the coupling between different types of nuclei, often a proton and an X-nucleus, such as carbon-13 or nitrogen-15. This method is commonly used in nuclear magnetic resonance (NMR) spectroscopy to gain insights into complex chemical compounds' structural and compositional aspects. A typical heteronuclear correlation spectrum displays X-nucleus chemical shifts on one axis and a proton spectrum on the other...
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NMR Spectrometers: Overview01:20

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NMR spectrometers consist of a strong magnet, a radiofrequency transmitter, and a detector attached to a computer console for recording spectra of samples containing NMR-active nuclei. In first-generation NMR instruments called continuous-wave spectrometers, the resonance frequencies of the nuclei are determined by frequency-sweep or field-sweep methods. The magnetic field strength is fixed and the rf signal is swept in the former, while the radiofrequency signal is fixed and the magnetic field...
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Surface NMR using quantum sensors in diamond.

Kristina S Liu1, Alex Henning2,3, Markus W Heindl1,2,3

  • 1Department of Chemistry, Technical University of Munich, Munich 85748, Germany.

Proceedings of the National Academy of Sciences of the United States of America
|January 27, 2022
PubMed
Summary

Nitrogen vacancy (NV) quantum sensors enable sensitive, surface-specific Nuclear Magnetic Resonance (NMR) detection on thin films. This breakthrough allows real-time, in situ analysis of molecular layers in catalysis and materials science.

Keywords:
NV center in diamondquantum sensingself-assembled monolayerspectroscopysurface analysis

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Area of Science:

  • Quantum Sensing
  • Surface Science
  • Spectroscopy

Background:

  • Nuclear Magnetic Resonance (NMR) is a powerful molecular characterization technique.
  • Traditional NMR lacks sensitivity for analyzing surfaces and interfaces due to low spin numbers.

Purpose of the Study:

  • To develop a surface-sensitive NMR technique using nitrogen vacancy (NV) centers in diamond.
  • To demonstrate the capability of NV-NMR for analyzing chemically modified thin films.

Main Methods:

  • Utilized NV centers in diamond as quantum sensors for optical NMR detection.
  • Prepared aluminum oxide thin films using atomic layer deposition.
  • Functionalized surfaces with phosphonate chemistry to create self-assembled monolayers.
  • Employed surface NV-NMR to detect and quantify monolayer signals.

Main Results:

  • Spatially resolved NMR signals were detected from self-assembled monolayers on aluminum oxide.
  • The technique confirmed chemical binding and quantified molecular coverage.
  • Real-time monitoring of solid-liquid interface formation kinetics was achieved.
  • Demonstrated femtomole sensitivity for in situ analysis.

Conclusions:

  • NV quantum sensors provide a novel, surface-sensitive NMR tool.
  • This method offers high sensitivity for in situ analysis in catalysis, materials, and biological research.