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Radical Radiation Therapy for Radiation-Induced Angiosarcoma with Local Control
Tsutomu Ikenohira1, Kenta Konishi1, Masanori Hirata1
1Department of Radiation Oncology, Hamamatsu University School of Medicine, Shizuoka, Japan.
Case Reports in Oncology
|January 27, 2022
Summary
This study shows radical radiotherapy can effectively treat radiation-induced angiosarcoma, even when unresectable. This approach offers a viable treatment option for patients with this rare cancer.
Area of Science:
- Oncology
- Radiation Oncology
Background:
- Angiosarcoma, particularly radiation-induced angiosarcoma, is often considered radioresistant.
- Surgical intervention is the typical treatment for radiation-induced angiosarcoma.
- No established effective treatments exist for radiation-induced angiosarcoma.
Observation:
- A case of unresectable radiation-induced angiosarcoma following breast cancer surgery is presented.
- The patient, a 78-year-old female, had a large, infiltrating tumor.
- Initial treatment involved radical radiotherapy (66 Gy).
Findings:
- The tumor showed remarkable reduction after radiotherapy.
- The patient experienced grade 2 dermatitis as the primary acute adverse effect.
- Subsequent pazopanib treatment was discontinued due to wound complications; external pneumothorax resolved with conservative care.
Implications:
- Radical radiotherapy can achieve excellent local control in select cases of angiosarcoma.
- Radiotherapy should be considered a potential treatment modality for inoperable angiosarcoma.
- This case challenges the notion of universal radioresistance in angiosarcoma.
