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Related Experiment Video

Updated: Oct 5, 2025

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
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Age-Related Decrease in Default-Mode Network Functional Connectivity Is Accelerated in Patients With Major Depressive

Shixiong Tang1,2, Zhipeng Wu3, Hengyi Cao4,5

  • 1Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.

Frontiers in Aging Neuroscience
|January 27, 2022
PubMed
Summary
This summary is machine-generated.

Major depressive disorder (MDD) is linked to faster brain aging. MDD patients show a more rapid decline in default-mode network functional connectivity with age compared to healthy individuals.

Keywords:
agingdynamic brain networkdynamic functional connectivity (dFC)fMRIfunctional connectivitymajor depressive disorder

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Aging Research

Background:

  • Major Depressive Disorder (MDD) is associated with accelerated biological aging.
  • The impact of MDD on brain function aging, particularly the default-mode network (DMN), remains unclear.

Purpose of the Study:

  • To investigate whether MDD is characterized by accelerated aging of DMN functions.
  • To examine age-related changes in functional connectivity (FC) and dynamic functional connectivity (dFC) within the DMN in MDD patients and healthy controls (HCs).

Main Methods:

  • Utilized resting-state functional magnetic resonance imaging (fMRI) data from 971 MDD patients and 902 HCs from a Chinese multicenter dataset.
  • Calculated DMN's FC strength and dFC temporal variability.
  • Employed linear regression models to assess age-related effects on FC/dFC, including diagnosis-by-age interactions, controlling for covariates.

Main Results:

  • A significant main effect of age was observed on both DMN FC strength and dFC variability in both groups.
  • MDD diagnosis significantly impacted DMN FC strength and showed a significant diagnosis-by-age interaction.
  • Age-related decline in DMN FC strength was more pronounced in MDD patients than in HCs.

Conclusions:

  • Both healthy individuals and MDD patients exhibit age-related changes in DMN function (decreased FC strength, increased dFC variability).
  • MDD patients may experience a faster rate of age-related decline in DMN functional connectivity.
  • Further longitudinal studies are required to establish causality between MDD and accelerated brain aging.