Related Experiment Video
Updated: Oct 5, 2025
A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
Published on: February 18, 2022
Hypertensive Heart Failure in Asia
Helsi Rismiati1, Hae-Young Lee1
1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Insights
Effective blood pressure control is crucial for preventing and managing hypertensive heart failure (HHF), particularly in Asian populations where it is a leading cause of heart failure. Managing hypertension is key to reversing cardiac dysfunction.
Area of Science:
- Cardiology
- Hypertension Research
- Heart Failure Studies
Background:
- Hypertension (HT) is a significant risk factor for heart failure (HF).
- The prevalence of HT-related HF is notably higher in Asia, where it is a primary cause of HF.
- Hypertensive heart failure (HHF) arises from cardiac structural and functional changes, including left ventricular hypertrophy (LVH).
Purpose of the Study:
- To review the epidemiology, pathophysiology, outcomes, and blood pressure (BP) management implications for HHF.
- To focus specifically on the Asian population, given the higher prevalence of HHF in this region.
Main Methods:
- Literature review focusing on hypertensive heart failure.
- Analysis of epidemiological data, pathophysiological mechanisms, and clinical outcomes.
- Examination of the role of blood pressure management in HHF.
Main Results:
- Hypertensive LVH contributes to diastolic dysfunction and increases risk for myocardial infarction, leading to systolic dysfunction.
- Asymptomatic LV dysfunction can progress to overt HF.
- Effective BP control can reverse HHF, highlighting its importance in primary and secondary HF prevention.
Conclusions:
- Hypertension control is essential for both preventing and treating hypertensive heart failure.
- Understanding HHF in the Asian population is critical due to regional prevalence.
- Further research into HHF pathophysiology and management strategies is warranted.
Abstract:
Hypertension (HT) is an important risk factor for heart failure (HF). The prevalence of HT among the HF population is higher in Asia than in other regions around the world. In Asia, HT is the most common cause of HF after ischemic heart disease. Hypertensive HF (HHF) results from structural and functional adaptations of the heart, which lead to left ventricular (LV) hypertrophy (LVH). Hypertensive LVH can cause ventricular diastolic dysfunction and becomes a risk factor for myocardial infarction, which is a well-known cause of LV systolic dysfunction. Asymptomatic systolic and diastolic LV dysfunction easily progress to clinically overt HF with other precipitating factors. Although the precise pathophysiology of HHF is still unclear, we have known that HHF can be reversed by effective control of blood pressure (BP). Thus, HT control is essential not only for primary prevention but also for the secondary prevention of HF. Here, we reviewed the epidemiology, pathophysiology, outcome, and implication of BP management in HHF patients, especially in the Asian population.
More Related Videos
07:41A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats
Published on: March 1, 2022
07:49Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
Published on: July 21, 2023
Related Concept Videos
01:17Pathophysiology of Heart Failure
01:27Heart Failure I: Introduction
01:29Heart Failure II: Pathophysiology
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
01:30Heart Failure IV: Classification and Diagnostic Evaluation
01:30Heart Failure V: Medical Management