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Related Experiment Video

Updated: Oct 5, 2025

Formulation and Acoustic Modulation of Optically Vaporized Perfluorocarbon Nanodroplets
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Perfluorocarbon Emulsion Contrast Agents: A Mini Review.

Ryan Holman1, Orane Lorton1, Pauline C Guillemin1

  • 1Image Guided Interventions Laboratory (GR-949), Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Frontiers in Chemistry
|January 27, 2022
PubMed
Summary

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Perfluorocarbon emulsions are versatile medical imaging agents with theranostic potential. Their high fluorine content and prior regulatory approval make them promising for new commercial contrast agents, especially with advancing MRI technology.

Area of Science:

  • Medical Imaging
  • Nanotechnology
  • Radiochemistry

Background:

  • Perfluorocarbon emulsions are utilized across various radiological imaging modalities.
  • These emulsions have demonstrated potential in theranostics, combining diagnostic and therapeutic capabilities.
  • Advancements in MRI technology, particularly 19F-MRI coils, are increasing interest in these agents.

Purpose of the Study:

  • To review the chemistry and physics of perfluorocarbon emulsions as contrast agents.
  • To highlight current and potential applications of perfluorocarbon emulsions in medical imaging.
  • To discuss the future prospects of perfluorocarbon emulsions in commercial imaging.

Main Methods:

  • Literature review of perfluorocarbon emulsion applications.
Keywords:
contrast agentsemulsionsfluorine chemistryperfluorocarbonsradiology

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  • Analysis of chemical and physical properties relevant to imaging.
  • Exploration of theranostic and commercialization potential.

    • Main Results:

    • Perfluorocarbon emulsions are compatible with MRI, ultrasonography, CT, and PET.
    • High fluorine content and existing regulatory approval support their use as imaging agents.
    • Theranostic applications and commercial potential are significant.

    Conclusions:

    • Perfluorocarbon emulsions represent a promising class of contrast agents for diverse medical imaging applications.
    • Their unique properties facilitate theranostic approaches and commercial development.
    • Continued research into their chemistry, physics, and applications will drive innovation in medical imaging.