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FAIM-L - SIVA-1: Two Modulators of XIAP in Non-Apoptotic Caspase Function

Elena Coccia1,2,3, Montse Solé1,2,3, Joan X Comella1,2,3

  • 1Cell Signaling and Apoptosis Group, Vall d'Hebron Institute of Research (VHIR), Barcelona, Spain.

Frontiers in Cell and Developmental Biology
|January 27, 2022
PubMed

Insights

Learn how FAIM-L and SIVA-1 regulate caspase activity in neurons, impacting synaptic plasticity and neurodegeneration. These functional antagonists are key to neuronal remodeling and survival.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

Background:

  • Apoptosis is vital for nervous system development.
  • Caspases, executioners of apoptosis, also regulate neuronal adaptiveness in adulthood.
  • FAIM-L and SIVA-1 are key regulators of caspase activation.

Purpose of the Study:

  • To review FAIM-L and SIVA-1 as functional antagonists modulating non-apoptotic caspase activity in neurons.
  • To describe their roles in long-term depression and neurite pruning.
  • To explore the association of FAIM-L's non-apoptotic functions with neurodegeneration.

Main Methods:

  • Literature review of recent studies on FAIM-L and SIVA-1.
  • Analysis of molecular pathways involving caspase regulation.
  • Examination of synaptic plasticity and neurite remodeling mechanisms.

Main Results:

  • FAIM-L and SIVA-1 act as functional antagonists in neuronal caspase regulation.
  • These proteins influence synaptic pruning and long-term depression.
  • Non-apoptotic roles of FAIM-L are linked to neurodegenerative processes.

Conclusions:

  • FAIM-L and SIVA-1 are critical modulators of non-apoptotic caspase functions in neurons.
  • Understanding their roles is essential for comprehending neuronal remodeling and neurodegeneration.
  • Targeting these pathways may offer therapeutic strategies for neurological disorders.
Keywords:
Alzheimer's diseaseXIAP antagonistaxon remodelingpruningsynaptic plasticity (LTP/LTD)

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