Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Oct 5, 2025

Neuromodulation and Mitochondrial Transport: Live Imaging in Hippocampal Neurons over Long Durations
04:50

Neuromodulation and Mitochondrial Transport: Live Imaging in Hippocampal Neurons over Long Durations

Published on: June 17, 2011

16.9K

Edelman Revisited: Concepts, Achievements, and Challenges.

Mark Rohrscheib1, Ramin Sam2, Dominic S Raj3

  • 1Department of Medicine, University of New Mexico School of Medicine, Albuquerque, NM, United States.

Frontiers in Medicine
|January 27, 2022
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comprehensive evaluation of reference miRNA for extracellular miRNA quantification in CKD.

Methods (San Diego, Calif.)·2026
Same author

Education Intervention for Evaluation and Living Donor Kidney Transplantation: A randomized trial.

medRxiv : the preprint server for health sciences·2026
Same author

Quantifying Change in Proteinuria After Acute Kidney Injury Among Patients With Chronic Kidney Disease: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.

Kidney medicine·2026
Same author

Optimizing Proteinuria Evaluation and Management after Acute Kidney Injury: Insights from the Chronic Renal Insufficiency Cohort Study.

Kidney360·2026
Same author

Response to the "Letter to the Editor: Prebiotic Administration to Chronic Kidney Disease Patients Modifies Their Microbiome and Metabolism".

Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation·2026
Same author

Relationship Between Baseline and Longitudinal Self-Reported Physical Function and Cardiorenal Outcomes in CKD: Findings From the CRIC Study.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
This summary is machine-generated.

The Edelman study shows that changes in the ratio of body sodium and potassium to body water affect serum sodium levels. Accurate treatment of dysnatremia requires accounting for all fluid and electrolyte shifts.

Area of Science:

  • Nephrology
  • Endocrinology
  • Internal Medicine

Background:

  • The 1958 Edelman study established that the ratio of total body sodium plus total body potassium to total body water influences serum sodium concentration.
  • Current quantitative methods for correcting dysnatremias are based on this principle.
  • However, inaccuracies in formulas can arise from unaddressed external losses and incorrect body water values.

Purpose of the Study:

  • To review the foundational principles of serum sodium regulation.
  • To discuss factors that may affect the accuracy of current dysnatremia treatment formulas.
  • To highlight emerging factors influencing serum sodium concentration during treatment.

Main Methods:

  • Review of the 1958 Edelman study and subsequent supporting research.
Keywords:
dysnatremiahydrophilic compoundshypernatremiahyponatremiaosmotic sodium inactivation

Related Experiment Videos

Last Updated: Oct 5, 2025

Neuromodulation and Mitochondrial Transport: Live Imaging in Hippocampal Neurons over Long Durations
04:50

Neuromodulation and Mitochondrial Transport: Live Imaging in Hippocampal Neurons over Long Durations

Published on: June 17, 2011

16.9K
  • Analysis of factors affecting serum sodium concentration ([Na]S).
  • Discussion of potential impacts on dysnatremia treatment strategies.

    • Main Results:

    • The core principle of serum sodium concentration ([Na]S) regulation by the (Na+K)/Water ratio remains valid.
    • External fluid and electrolyte losses during treatment can compromise formula accuracy.
    • Newly identified factors include intracellular sodium shifts, water binding to macromolecules, and genetic influences.

    Conclusions:

    • Existing formulas for dysnatremia correction may be limited by unconsidered variables.
    • Emerging factors require further investigation to refine treatment protocols.
    • Continuous monitoring of serum sodium concentration is essential during dysnatremia management.