Teratological effects of titanium dioxide nanoparticles in mice embryo

Nanoparticles have numerous applications related to human uses. Titanium dioxide nanoparticles (TiO₂-NPs) are extensively used in many daily utilities. The small size particles and larger uses in the industry have led them to become a threatening entity to the living organisms. The unchecked use and dumping in the environment poses a significant toxicological risk to the developing mammalian embryo. The present study was conducted to determine the developmental toxicity and teratogenic effects of TiO₂-NPs in murine embryos. The TiO₂-NPs were introduced intravenously into pregnant mice graded as T1 (0.52 mg/g BW), T2 (0.7 mg/g BW), and T3 (1.05 mg/g BW) along with control with no dose administration T0 (0.00 mg/g BW). Results recorded after 14 days were resorbed fetuses, dropped wrist, hemorrhages, sacral hygromas, and kinked tails. It was concluded that the exposure of TiO₂-NPs in mentioned doses from any source may lead to deleterious effects on the development of an embryo.