Risks of ozonated oil and ozonated water on human skin: A systematic review

Area of Science:

• Dermatology
• Biomedical Science
• Ozone Therapy

Background:

• Ozonated water and oil are increasingly recognized for their therapeutic potential in dermatology, especially for wound management.
• Despite their growing use, comprehensive safety data regarding the application of ozonated liquids on human skin remains limited.
• This systematic review addresses the need to evaluate the potential risks associated with these emerging dermatologic treatments.

Approach:

• A systematic literature search was conducted across five scientific databases, yielding 378 articles.
• Inclusion and exclusion criteria were applied, resulting in the selection of nine relevant studies for review.
• The included studies comprised cytotoxicity assessments, randomized controlled trials (RCTs), post-market surveillance, and human crossover studies.

Key Points:

• The review found no significant adverse dermatologic risks in humans associated with the use of ozonated water or ozonated oil.
• Two studies specifically investigated the cytotoxicity of ozonated liquids on human cells.
• Five studies involved randomized controlled trials (RCTs) evaluating the efficacy and safety of ozonated liquids in dermatologic applications.

Conclusions:

• Current literature suggests that ozonated liquids are safe for dermatologic use in humans, with no identified significant risks.
• The existing evidence, while promising, is based on a limited number of studies and small sample sizes.
• Further short-term and long-term randomized controlled trials are recommended to definitively establish the dermatological safety profile of ozonated liquids.