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Affective lability and social functioning in severe mental disorders.

Margrethe Collier Høegh1, Ingrid Melle2, Sofie R Aminoff2,3

  • 1NORMENT, Centre for Research On Mental Disorders, Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, Bygg 49, Ullevål sykehus, Nydalen, PO Box 4956, 0424, Oslo, Norway. m.c.hoegh@medisin.uio.no.

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PubMed
Summary

Elevated affective lability negatively impacts social functioning in severe mental disorders, even after accounting for other factors. Targeting mood instability may improve psychosocial recovery in these conditions.

Keywords:
Affective labilityAffective lability Scale Short Form (ALS-SF)Bipolar spectrumPsychotic disordersSchizophrenia spectrumSocial functioning

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Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Neuroscience

Background:

  • Social functioning deficits persist in severe mental disorders despite clinical remission.
  • Affective lability is heightened in psychosis spectrum disorders, contributing to clinical burden.

Purpose of the Study:

  • To investigate the association between affective lability and social functioning in severe mental disorders.
  • To determine if this association is independent of known predictors of social impairment.

Main Methods:

  • 293 participants with schizophrenia- and bipolar spectrum disorders were assessed.
  • Affective lability was measured using the Affective Lability Scale (ALS-SF).
  • Social functioning was assessed using the Social Functioning Scale (SFS); analyses included correlations and hierarchical multiple regression.

Main Results:

  • Higher scores on all ALS-SF subdimensions (anxiety-depression, depression-elation, anger) were significantly linked to lower social functioning.
  • The association between anxiety-depression and social functioning remained significant after controlling for confounders like premorbid functioning and current symptoms.

Conclusions:

  • Elevated affective lability is a significant factor negatively impacting social functioning in severe mental disorders.
  • Targeting affective lability may be a promising strategy for improving psychosocial outcomes in these patient populations.