Related Experiment Video For adenocarcinoma
Updated: Oct 5, 2025

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
Published on: September 20, 2016
Sarcomatoid change in adenocarcinoma arising in adulthood congenital pulmonary airway malformation
Valentina Tassi1, Niccolò Daddi2, Annalisa Altimari3
1Division of Thoracic Surgery Maria Cecilia Hospital, Cotignola, Italy. vtassi82@gmail.com.
Abstract:
Congenital pulmonary airway malformations (CPAM) are rare conditions generally diagnosed in childhood and possibly harboring malignant tumor growths. We describe a unique case of pleomorphic carcinoma in a longstanding type 1 CPAM diagnosed by wedge resection. The patient underwent completion left lower lobectomy and lymphadenectomy, but cancer recurred in nodal station #7 six months later. Clinicians should keep in mind that CPAM may hide radiologically undetectable malignancy in a relevant rate of cases, then requiring surgery in all patients. While MIA is the most common histology in type 1 CPAM, sarcomatoid change has herein been demonstrated.
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