Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Defending the Ethical Permissibility of Laryngeal Transplantation.

The American journal of bioethics : AJOB·2026
Same author

Computational validation and network pharmacology reveal the cardioprotective and hypolipidemic potential of <i>Arisaema Jacquemontii Blume</i> via molecular docking, metadynamics, DFT, and MM/PBSA analyses.

Frontiers in bioinformatics·2026
Same author

Antigen Removal Approach to Murine Larynx Engineering Optimizes Extracellular Matrix Preservation.

The Laryngoscope·2026
Same author

Genome-guided discovery and computational prioritization of next generation drug development from <i>Streptomyces</i> sp. VITGV156 (MCC 4965).

Frontiers in microbiology·2026
Same author

Laryngeal Chondrosarcoma: A SEER Database Analysis.

The Laryngoscope·2026
Same author

Impact of reminder messages, with and without financial incentives, on influenza vaccination: A randomized trial in a California health system.

Vaccine·2026

Related Experiment Video

Updated: Oct 5, 2025

A Heterotopic Mouse Model for Studying Laryngeal Transplantation
14:15

A Heterotopic Mouse Model for Studying Laryngeal Transplantation

Published on: January 13, 2023

3.0K

A Tissue Engineered Construct for Laryngeal Regeneration: A Proof-of-Concept Device Design Study.

David G Lott1,2, Manisha Shah1, Cheryl Myers1

  • 1Head and Neck Regenerative Medicine Laboratory, Mayo Clinic Arizona, Scottsdale, Arizona, U.S.A.

The Laryngoscope
|January 27, 2022
PubMed
Summary

This study developed a patient-specific tissue-engineered construct for laryngeal reconstruction. The construct successfully restored voicing, breathing, and eating functions in a canine model after one year.

Keywords:
Tissue engineeringairway reconstructionepithelializationpartial laryngectomy

More Related Videos

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats
08:56

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats

Published on: February 10, 2020

7.3K
Construction and Characterization of a Novel Vocal Fold Bioreactor
11:11

Construction and Characterization of a Novel Vocal Fold Bioreactor

Published on: August 1, 2014

9.3K

Related Experiment Videos

Last Updated: Oct 5, 2025

A Heterotopic Mouse Model for Studying Laryngeal Transplantation
14:15

A Heterotopic Mouse Model for Studying Laryngeal Transplantation

Published on: January 13, 2023

3.0K
Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats
08:56

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats

Published on: February 10, 2020

7.3K
Construction and Characterization of a Novel Vocal Fold Bioreactor
11:11

Construction and Characterization of a Novel Vocal Fold Bioreactor

Published on: August 1, 2014

9.3K

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Surgical Innovation

Background:

  • Partial laryngectomy necessitates reconstructive solutions.
  • Current reconstructive methods have limitations.
  • Tissue engineering offers a promising alternative for laryngeal repair.

Purpose of the Study:

  • To develop and evaluate a patient-specific tissue-engineered construct for laryngeal reconstruction.
  • To assess the functional and histological outcomes of the construct in a preclinical model.

Main Methods:

  • A porous polyethylene scaffold was customized and seeded with autologous canine adipose-derived stem cells in fibrin glue.
  • The construct was implanted in a canine following a partial laryngectomy.
  • In vivo functional assessment (voicing, breathing, eating) and histological evaluation were performed after one year.

Main Results:

  • The engineered construct facilitated normal voicing, breathing, and eating functions in the canine model at one year.
  • Acoustic and aerodynamic measures were within normal ranges.
  • The construct showed good integration and epithelialization, with no need for additional anti-infective agents.

Conclusions:

  • This study represents a significant advancement in developing patient-specific composite constructs for laryngeal reconstruction.
  • The findings support the potential of tissue-engineered solutions for patients undergoing partial laryngectomies.