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Project-based learning course on metabolic network modelling in computational systems biology.

Thomas Sauter1, Tamara Bintener1, Ali Kishk1

  • 1Systems Biology Group, Department of Life Sciences and Medicine, University of Luxembourg, Belvaux, Luxembourg.

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Summary

This study details a successful project-based learning (PBL) course in metabolic network modeling for integrated systems biology students. The dynamic approach fosters critical thinking and engagement through real-world problem-solving using constraint-based modeling (CBM).

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Area of Science:

  • Systems Biology
  • Computational Biology
  • Biotechnology Education

Background:

  • Project-based learning (PBL) is an effective pedagogical approach for science education.
  • Metabolic network modeling is a key technique in systems biology.
  • Integrated Systems Biology programs require interdisciplinary skills.

Purpose of the Study:

  • To describe a Project-based learning (PBL) course in metabolic network modeling.
  • To share the course structure, content, and outcomes for the Master in Integrated Systems Biology (MISB).
  • To provide a model for similar educational initiatives.

Main Methods:

  • A 2-week full-time block course structure was implemented.
  • Constraint-based modeling (CBM) concepts and methods were taught.
  • Students prepared and executed individual projects using metabolic network models.

Main Results:

  • The course successfully integrated theoretical concepts with practical application.
  • Student engagement and critical thinking were fostered through problem-solving.
  • Exemplary student projects demonstrated mastery of metabolic network modeling techniques.

Conclusions:

  • The PBL course offers a rewarding teaching and learning experience.
  • The course design can serve as a valuable model for other institutions.
  • PBL effectively prepares students for complex challenges in systems biology.