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Related Experiment Video

Updated: Oct 5, 2025

Methods to Classify Cytoplasmic Foci as Mammalian Stress Granules
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Screening Linear and Circular RNA Transcripts from Stress Granules.

Shuai Chen1, Jinyang Zhang2, Fangqing Zhao3

  • 1Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.

Genomics, Proteomics & Bioinformatics
|January 27, 2022
PubMed
Summary

Circular RNAs (circRNAs) are newly identified components of stress granules (SGs), cytoplasmic assemblies linked to diseases. This study reveals circRNAs

Keywords:
Circular RNAHepatocellular carcinomaProtein–RNA interactionRNA-seqStress granule

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Last Updated: Oct 5, 2025

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genomics

Background:

  • Stress granules (SGs) are dynamic cytoplasmic foci of proteins and RNA, crucial for cellular stress response and implicated in various diseases.
  • While the roles of proteins and linear RNAs in SG formation are established, the involvement of circular RNAs (circRNAs) remains unexplored.
  • Investigating the interplay between circRNAs and SGs is essential for understanding cellular stress responses and disease mechanisms.

Discussion:

  • This study identifies specific circular RNAs (circRNAs) localized within purified stress granule (SG) cores.
  • The enrichment of circRNAs in SGs correlates with their binding affinity to SG-related RNA-binding proteins (RBPs).
  • Differential expression of certain SG-enriched circRNAs in hepatocellular carcinoma (HCC) suggests their potential role in disease pathogenesis.

Key Insights:

  • Circular RNAs (circRNAs) are novel components of stress granules (SGs).
  • circRNA localization and enrichment in SGs are influenced by RNA-binding protein interactions.
  • SG-associated circRNAs exhibit altered expression in hepatocellular carcinoma (HCC).

Outlook:

  • Further research is needed to elucidate the precise functions of circRNAs within SGs.
  • Exploring circRNAs as potential biomarkers or therapeutic targets in stress-related diseases like HCC.
  • Investigating the biogenesis and regulatory mechanisms of circRNAs in the context of cellular stress.