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A ZIF-8-based multifunctional intelligent drug release system for chronic osteomyelitis

Yongmei Ge1, Kui Wang2, Jiayi Liu3

  • 1Harbin Institute of Technology, Harbin, Heilongjiang 150001, China; Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China.

Colloids and Surfaces. B, Biointerfaces
|January 27, 2022
PubMed

Insights

A novel pH-responsive drug delivery system, CEL@ZIF-8, effectively treats chronic osteomyelitis (COM). It exhibits antibacterial, osteogenic, and anti-inflammatory properties, offering a promising new approach for COM management.

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Chronic osteomyelitis (COM) is a challenging bone infection.
  • Current antibiotic treatments for COM face limitations like resistance and side effects.
  • Effective treatment requires addressing infection, inflammation, and bone loss simultaneously.

Purpose of the Study:

  • To develop a multifunctional, pH-responsive drug delivery system for COM treatment.
  • To utilize ZIF-8 nanoparticles and celecoxib for targeted drug release.
  • To evaluate the system's efficacy in combating bacterial infection and promoting bone healing.

Main Methods:

  • Fabrication of CEL@ZIF-8 by loading celecoxib into ZIF-8 nanoparticles.
  • Characterization of material properties and drug loading efficiency.
  • In vitro assessment of pH-responsive drug release, antibacterial activity, and cellular effects.

Main Results:

  • Successful synthesis and characterization of CEL@ZIF-8 with efficient celecoxib loading.
  • Demonstrated pH-responsive ion and drug release capabilities.
  • Significant inhibition of bacterial growth and promotion of osteogenesis-related gene expression.
  • Down-regulation of inflammatory factors in vitro.

Conclusions:

  • CEL@ZIF-8 is a multifunctional system with antibacterial, osteogenic, and anti-inflammatory properties.
  • The pH-responsive nature enables intelligent drug release for COM treatment.
  • This novel system shows significant potential for clinical application in managing chronic osteomyelitis.
Keywords:
Anti-inflammatoryAntibacterialChronic osteomyelitisIntelligent releaseOsteogenesis

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