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Published on: August 28, 2018
Mitral Annulus Calcification and Cardiac Conduction Disturbances: A DANCAVAS Sub-study
Jeppe Holm Rasmussen1,2, Maise Hoeigaard Fredgart1, Jes Sanddal Lindholt3
1Department of Cardiology, Odense University Hospital, Odense, Denmark.
Journal of Cardiovascular Imaging
|January 27, 2022
Summary
Mitral annulus calcification (MAC) is linked to atrioventricular (AV) conduction disturbances, particularly those requiring pacemakers. This finding may enhance understanding of AV conduction issues.
Area of Science:
- Cardiology
- Medical Imaging
- Electrophysiology
Background:
- Mitral annulus calcification (MAC) proximity to the His bundle suggests a potential link to atrioventricular (AV) conduction disturbances.
- Understanding this association is crucial for predicting and managing cardiac conduction abnormalities.
Purpose of the Study:
- To assess the association between MAC and AV conduction disturbances using cardiac implantable electronic device (CIED) data and electrocardiographic parameters.
- To investigate the relationship between MAC and traditional cardiovascular risk factors.
Main Methods:
- Cross-sectional analysis of 14,771 participants from the Danish Cardiovascular Screening trial.
- MAC quantification using cardiac non-contrast computed tomography (Agatston method).
- CIED data from the Danish Pacemaker and Implantable Cardioverter Defibrillator Register; ECG analysis for 2,107 participants.
Main Results:
- MAC was present in 22.4% of subjects.
- Higher MAC scores were significantly associated with pacemaker implantation for AV conduction disturbances (OR, 1.11; 95% CI, 1.01-1.23).
- Prolonged QRS interval showed a significant association with MAC presence (OR, 1.45; 95% CI, 1.04-2.04). Female sex and cardiovascular risk factors correlated with high MAC scores.
Conclusions:
- Mitral annulus calcification is associated with atrioventricular conduction disturbances.
- This association may improve the understanding of the etiology of AV conduction disturbances.
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