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Neonatal necrotizing enterocolitis in Lagos.

S D Adeyemi1, I Ahmed

  • 1Department of Surgery, Lagos University Teaching Hospital, University of Lagos, Nigeria.

Scandinavian Journal of Gastroenterology. Supplement
|January 1, 1986
PubMed
Summary

Neonatal Necrotizing Enterocolitis (NNEC) affects infants in their second week of life, with infections as a likely cause. Medical management, including intravenous metronidazole, shows promise for treating acute NNEC, especially in developing nations.

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Area of Science:

  • Pediatrics
  • Neonatology
  • Infectious Diseases

Background:

  • Neonatal Necrotizing Enterocolitis (NNEC) is a serious gastrointestinal condition affecting newborns.
  • Understanding predisposing factors and effective treatments for NNEC is crucial for improving infant outcomes.

Purpose of the Study:

  • To analyze the clinical presentation and outcomes of infants diagnosed with NNEC between 1978 and 1984.
  • To evaluate the efficacy of medical versus surgical management for acute NNEC.

Main Methods:

  • Retrospective review of medical records for 14 infants diagnosed with NNEC.
  • Analysis of presenting features, predisposing factors, and treatment strategies.

Main Results:

  • NNEC typically presented in the second week of life, affecting both preterm and term infants equally.

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  • Infections were implicated as a predisposing factor, though no specific pathogens were identified.
  • Abdominal distention, rectal bleeding, and bowel perforation were common features. Medical management with intravenous metronidazole was associated with survival in three cases.

    • Conclusions:

    • Extended medical management, including intravenous metronidazole, is suggested for acute NNEC in developing countries.
    • Surgical intervention should be reserved for cases of perforation and uncontrollable rectal bleeding.