Systematic comparison of basic animal models of cerebral hypoperfusion

Various surgical interventions into the head and neck vasculature differentially impact nature, localization and dynamics of ischemic changes in the brain structures. In this regard, our review aims to compare the time course of basic cellular and molecular mechanisms. Selection of a animals model should be done along the following criteria: development of oxidative stress in brain cells, blood-brain barrier breakdown, glial activation and neuroinflammation, alterations in angiogenesis; reproducibility of the model.