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Natural Products Against COVID-19 Inflammation: A Mini-Review
Simone Mendes Lopes1, Herbert Igor Rodrigues de Medeiros1, Marcus Tullius Scotti1
1Postgraduate Program in Natural and Synthetic Bioactive Products (PgPNSB), Health Sciences Center, Federal University of Paraíba, João Pessoa Pb, Brazil.
Abstract:
Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) is a virus whose genetic material is positive single-stranded RNA, being responsible for coronavirus disease 2019 (COVID- 19), an infection that compromises the lungs and consequently the respiratory capacity of the infected individual, according to the WHO in November 2021, 249,743,428 cases were confirmed, of which 5,047,652 individuals died due to complications resulting from the infection caused by SARSCOV- 2. As the infection progresses, the individual may experience loss of smell and taste, as well as breathing difficulties, severe respiratory failure, multiple organ failure, and death. Due to this new epidemiological agent in March 2020 it was announced by the director general of the World Health Organization (WHO) a pandemic status, and with that, many research groups are looking for new therapeutic alternatives through synthetic and natural bioactives. This research is a literature review of some in silico studies involving natural products against COVID-19 inflammation published in 2020 and 2021. Work like this presents relevant information to the scientific community, boosting future research and encouraging the use of natural products for the search for new antivirals against COVID-19.
Insights
This review explores natural products as potential treatments for COVID-19 inflammation. It highlights in silico studies identifying natural compounds that may offer new antiviral therapies.
Area of Science:
- Virology and Immunology
- Natural Product Chemistry
- Computational Drug Discovery
Background:
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a global pandemic with significant mortality.
- The virus targets the respiratory system, leading to severe complications including respiratory and multiple organ failure.
- The urgent need for effective therapeutics drives research into both synthetic and natural bioactive compounds.
Approach:
- This study conducted a literature review of in silico research published in 2020 and 2021.
- The focus was on computational studies investigating natural products for their potential anti-inflammatory effects against SARS-CoV-2.
- The review synthesizes findings from various in silico investigations.
Key Points:
- In silico studies are crucial for initial screening of natural products against viral targets.
- Several natural compounds show promise in preclinical computational models for mitigating COVID-19 related inflammation.
- Natural products offer a diverse chemical scaffold for developing novel antiviral agents.
Conclusions:
- Natural products represent a promising avenue for discovering new antiviral drugs against COVID-19.
- Further research, including in vitro and clinical trials, is warranted to validate the efficacy of identified natural compounds.
- This review provides valuable insights for researchers seeking natural product-based solutions for COVID-19 treatment.
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