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Progress, evolving therapeutic/diagnostic approaches, and challenges in the management of hepatitis C virus

Rohan Janardhan Meshram1, Gunderao Hanumantrao Kathwate2, Rajesh Nivarti Gacche3

  • 1Bioinformatics Centre, Savitribai Phule Pune University, Pune, MS, 411007, India.

Archives of Virology
|January 28, 2022
PubMed

Insights

Hepatitis C virus (HCV) infection management is challenged by its chronic nature and viral diversity. This review explores novel therapeutic, prophylactic, and nanotechnology-based strategies to combat HCV and associated liver diseases.

Area of Science:

  • Hepatology and Virology
  • Immunology
  • Nanomedicine

Background:

  • Hepatitis C virus (HCV) infection poses a significant global health challenge, affecting over 170 million people worldwide.
  • Chronic HCV infection is linked to severe liver diseases, including cirrhosis and hepatocellular carcinoma.
  • Current HCV treatments require refinement, necessitating the development of tailored therapeutic and prophylactic strategies.

Purpose of the Study:

  • To provide an updated review of evolving therapeutic approaches and prophylactic measures for Hepatitis C virus (HCV) management.
  • To discuss established and experimental immune prophylactic strategies and vaccination developments against HCV.
  • To explore the application of nanotechnology in developing effective therapeutic interventions for HCV.

Main Methods:

  • Literature review of established and experimental therapeutic approaches.
  • Analysis of immune prophylactic measures and vaccination strategies.
  • Exploration of nanotechnology applications in HCV treatment formulation.

Main Results:

  • The review synthesizes current knowledge on HCV pathophysiology and treatment limitations.
  • It highlights advancements in immune-based prophylaxis and vaccine development.
  • The potential of nanotechnology for novel HCV therapeutic delivery systems is discussed.

Conclusions:

  • There is a critical need for novel, efficient, and cost-effective diagnostic and therapeutic interventions for HCV.
  • Further research into immune prophylaxis, vaccination, and nanomedicine is crucial for effective HCV management.
  • Addressing limitations in current diagnostics and treatments will drive innovation in combating HCV infection and its sequelae.

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