Current research scenario for biological effect of exogenous factors on microcystin synthesis

In natural water bodies, numerous cyanobacteria have the potential to intracellularly synthesize cyanotoxins, among which microcystin (MC) is the ubiquitous toxin that has been well known to be carcinogenic for hepatocytes. MC synthesis is a complex process, which involves about 10 non-ribosomal proteins encoded by the mcy gene cluster. In the natural environments containing MC-producing cyanobacteria, a variety of external factors can affect the generation of MC by mediating the expression of synthesizing genes. These factors can be generally divided into biotic factors (e.g., daphnia, virioplankton, MC-degrading bacteria, algicidal bacteria) and abiotic factors (e.g., nutrients, physical factors, chemicals, phytochemicals, essential trace elements), which are of great significance to the effective reduction of MC. Furthermore, comparison of MC-synthesizing genes in different cyanobacterial strains was performed, and the related factors affecting MC synthesis were summarized. Then, the problems and gaps regarding the biological effect of exogenous factors on microcystin synthesis were discussed. This review article may provide new ideas for addressing the challenges and bottlenecks of MC management.