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Updated: Oct 5, 2025

A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles

A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles

Published on: March 20, 2019

Optical Nanopore Sensors for Quantitative Analysis.

Jasper P Fried¹, Yanfang Wu¹, Richard D Tilley¹

¹School of Chemistry, Australian Centre for NanoMedicine, ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of New South Wales, Sydney, New South Wales 2052, Australia.

|January 28, 2022

Summary

This summary is machine-generated.

Optical nanopore sensing offers sensitive detection of biomarkers. This review covers optical strategies for quantitative analysis, multiplexing, and high-density array fabrication for clinical applications.

Keywords:

clinical diagnostics optical sensing single-molecule sensing solid-state nanopores ultrasensitive detection

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Last Updated: Oct 5, 2025

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Area of Science:

Biomedical Engineering
Nanotechnology
Analytical Chemistry

Background:

Nanopore sensors detect biomarkers at single-molecule resolution via ionic current changes.
Traditional nanopore sensing relies on electrical current measurements.
Optical readout strategies are emerging for quantitative nanopore sensing.

Purpose of the Study:

To review optical nanopore sensing strategies for quantitative analysis.
To discuss assays for detecting clinically relevant biomarkers.
To explore fabrication of high-density nanopore arrays for clinical use.

Main Methods:

Review of existing literature on optical nanopore sensing.
Discussion of assay development for biomarker detection.
Analysis of techniques for high-density nanopore array fabrication.

Main Results:

Optical nanopore sensing enables quantitative analysis using wide-field microscopy.
High-density arrays allow monitoring of numerous nanopores, increasing statistics.
This approach facilitates ultralow concentration analyte detection.

Conclusions:

Optical nanopore sensing provides a powerful platform for quantitative biomarker detection.
Multiplexing capabilities and high-density arrays are key for clinical applications.
Further development holds promise for sensitive and specific diagnostics.