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Neoplastic Cellularity Assessment in Molecular Testing.

Kelly A Devereaux1,2, Rhona J Souers3, Rondell P Graham4

  • 1From the Department of Pathology, Stanford University School of Medicine, Stanford, California (Devereaux).

Archives of Pathology & Laboratory Medicine
|January 28, 2022
PubMed
Summary
This summary is machine-generated.

Neoplastic cellularity assessment lacks standardized guidelines, leading to practice variations that can impact accuracy in molecular oncology testing. This study proposes best practices to improve consistency and reliability.

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Area of Science:

  • Oncology
  • Pathology
  • Laboratory Medicine

Background:

  • Neoplastic cellularity assessment is crucial for molecular oncology testing.
  • Current practices lack standardized guidelines, leading to variability.

Purpose of the Study:

  • To describe current neoplastic cellularity assessment practices globally.
  • To evaluate the impact of practice variations on assessment accuracy.

Main Methods:

  • Analysis of data from 57 laboratories participating in the 2019 College of American Pathologists Neoplastic Cellularity Proficiency Testing Survey (NEO-B 2019).
  • Survey included practice questions and digital image assessments compared to a manual cell count criterion standard.

Main Results:

  • Significant variations observed in laboratory practices, including definitions, methodologies, counting, and quality assurance.
  • Laboratory practice variations were found to affect neoplastic cellularity assessment performance.

Conclusions:

  • Highlights the need for a consensus definition and standardization of neoplastic cellularity assessment.
  • Presents initial best practice recommendations to guide standardization efforts.