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Related Concept Videos

Lagging Strand Synthesis01:59

Lagging Strand Synthesis

During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...
Ligand-gated Ion Channels01:19

Ligand-gated Ion Channels

Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that include the...
Ziegler–Natta Chain-Growth Polymerization: Overview01:17

Ziegler–Natta Chain-Growth Polymerization: Overview

Ziegler–Natta polymerization is another form of addition or chain‐growth polymerization used for synthesizing linear polymers over branched polymers. The catalyst used for polymerization is the Ziegler–Natta catalyst, named after Karl Ziegler and Giulio Natta, who developed it in 1953. This catalyst is an organometallic complex of titanium tetrachloride and triethyl aluminum, with the active form of the catalyst being an alkyl titanium compound. Using the Ziegler–Natta catalyst, high molecular...
Lagging Strand Synthesis01:59

Lagging Strand Synthesis

During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...
Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure to...
Ligand-gated Ion Channels01:19

Ligand-gated Ion Channels

Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that include the...

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Updated: Jun 23, 2026

Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation
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An open chat with… Laszlo Nagy.

Duncan E Wright1, Laszlo Nagy2,3

  • 1FEBS Open Bio Editorial Office, Cambridge, UK.

FEBS Open Bio
|January 28, 2022
PubMed
Summary
This summary is machine-generated.

Laszlo Nagy, a prominent researcher, shares career advice and insights into scientific publishing. He discusses advancements in metabolic disease research and future prospects for scientific infrastructure in Eastern Europe.

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Area of Science:

  • Biomedical Research
  • Metabolic Diseases
  • Scientific Publishing

Background:

  • Laszlo Nagy, Professor at Johns Hopkins School of Medicine, has a distinguished career in medicine and biological chemistry.
  • He holds leadership roles at The Johns Hopkins Center for Metabolic Origins of Disease and previously directed a program at Sanford Burnham Prebys Medical Discovery Institute.

Purpose of the Study:

  • To share transformative career advice from a leading scientist.
  • To discuss the evolving landscape of scientific publishing and the role of society journals.
  • To highlight new developments in metabolic disease research and future scientific infrastructure in Eastern Europe.

Main Methods:

  • The content is based on an interview with Laszlo Nagy.
  • Discussion of personal career trajectory and professional insights.
  • Overview of research initiatives and future outlooks.

Main Results:

  • Nagy provides actionable career advice that can alter professional paths.
  • He offers perspectives on the importance and future of society-based scientific journals.
  • New developments at the Johns Hopkins Center for Metabolic Origins of Disease are presented.

Conclusions:

  • Scientific careers can be significantly influenced by key advice and mentorship.
  • The future of scientific publishing requires adaptation and support for society journals.
  • Advancements in metabolic disease research and infrastructure development in Eastern Europe hold significant promise.