Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Oct 5, 2025

Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals
08:31

Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals

Published on: September 20, 2021

3.4K

Zoster Eye Disease Study: Rationale and Design.

Elisabeth J Cohen1, Judith S Hochman2, Andrea B Troxel3

  • 1Department of Ophthalmology, NYU Grossman School of Medicine, New York, NY.

Cornea
|January 28, 2022
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Engagement With Mobile Health Cardiac Rehabilitation Varies Widely Among Older Adults With Ischemic Heart Disease.

Journal of cardiopulmonary rehabilitation and prevention·2026
Same author

Provider comments reveal barriers to EHR nudge effectiveness: process evaluation of a null deprescribing trial.

Implementation science communications·2026
Same author

A Phase-2 Open-Label Trial of Cannabidiol to Treat Core and Associated Symptoms of Autism in Children and Adolescents Without Intellectual Disability.

Journal of child and adolescent psychopharmacology·2026
Same author

Distinguishing Factors for Microbial Keratitis Groups: A Cross-Sectional Survey of US Cornea Specialists.

Cornea·2026
Same author

Burden of Residual Angina Among Older Adults With Ischemic Heart Disease in the United States: Findings From the RESILIENT Trial.

Circulation. Population health and outcomes·2026
Same author

Efficacy and safety of cyclosporine 1% eye drops for the treatment of pediatric blepharokeratoconjunctivitis.

International journal of ophthalmology·2026

The Zoster Eye Disease Study (ZEDS) investigates if one year of valacyclovir prevents herpes zoster ophthalmicus (HZO) complications. This trial aims to establish evidence for optimal HZO patient care.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Clinical Trials

Background:

  • Herpes zoster ophthalmicus (HZO) can lead to serious eye complications.
  • Current evidence supporting suppressive antiviral therapy for HZO is limited.
  • The Zoster Eye Disease Study (ZEDS) addresses this gap in high-quality evidence.

Purpose of the Study:

  • To describe the rationale and design of the Zoster Eye Disease Study (ZEDS).
  • To determine if one year of suppressive valacyclovir reduces complications in patients with HZO.

Main Methods:

  • ZEDS is a randomized clinical trial enrolling immunocompetent adults with a history of HZO.
  • The primary endpoint is the time to new or worsening ocular inflammation or keratitis requiring treatment changes.
  • The study is powered to detect a 30% difference in endpoints between treatment groups.

More Related Videos

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK
07:27

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Published on: December 18, 2012

12.1K
Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
06:30

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

425

Related Experiment Videos

Last Updated: Oct 5, 2025

Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals
08:31

Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals

Published on: September 20, 2021

3.4K
Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK
07:27

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Published on: December 18, 2012

12.1K
Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
06:30

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

425

Main Results:

  • Over 400 participants have been enrolled in the ZEDS trial over approximately four years.
  • Enrollment data indicates feasibility of recruiting patients for this HZO study.

Conclusions:

  • The ZEDS trial is designed to provide crucial scientific evidence on the efficacy of suppressive valacyclovir for HZO.
  • Findings will inform whether suppressive valacyclovir should become the standard of care for HZO patients.