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[High altitude neonatal medicine in China: opportunities and challenges]

Z B Yu1, W H Zhou2

  • 1Department of Neonatology, Women's Hospital of Nanjing Medical University, Nanjing 210004, China.

Zhonghua Er Ke Za Zhi = Chinese Journal of Pediatrics
|January 28, 2022
PubMed
Abstract

No abstract available in PubMed .

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In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
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Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
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