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Related Experiment Videos

Decrease of CD38 expression is linked to increase of solitary plasmacytoma pathological grade: a single institution

Yueying Li1, Jianchun Guo1, Chunxiu Yang1

  • 1Department of Pathology, Zhongnan Hospital of Wuhan University, 430071 Wuhan, Hubei, China.

Frontiers in Bioscience (Landmark Edition)
|January 29, 2022
PubMed
Summary

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Solitary plasmacytoma (SP) is a rare plasma cell neoplasm. This study found extraosseous plasmacytoma (EP) more common than solitary plasmacytoma of bone (SPB), with CD38 potentially indicating prognosis.

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Solitary plasmacytoma (SP) is a rare plasma cell neoplasm.
  • Localized neoplastic proliferation of monoclonal plasma cells characterizes SP.
  • Further understanding of clinicopathologic features is needed due to SP's rarity.

Purpose of the Study:

  • To analyze clinicopathologic features of solitary plasmacytoma.
  • To compare solitary plasmacytoma of bone (SPB) and extraosseous plasmacytoma (EP).
  • To investigate potential prognostic markers for SP.

Main Methods:

  • Retrospective analysis of 13 solitary plasmacytoma cases.
  • Collection of clinical data.
  • Histopathological and immunohistochemical analyses, including CD38 expression and Ki-67 proliferation index.
Keywords:
CD38ExtraosseousImmunohistochemistryPlasmacytomaSolitary

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Main Results:

  • Extraosseous plasmacytoma (EP) was more common (69.2%) than solitary plasmacytoma of bone (SPB) (30.8%).
  • EP cases were diagnosed in older patients compared to SPB.
  • Tumor cells expressed CD38, CD138, MUM-1, and showed light chain restriction; CD38 expression was decreased in neoplastic cells.

Conclusions:

  • Solitary plasmacytoma (SP) is a rare neoplasm in older patients.
  • Diagnosis requires integrated clinical and pathological assessment.
  • CD38 may serve as a prognostic marker for SP, warranting further investigation.