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Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
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Circular RNAs and glioblastoma multiforme: focus on molecular mechanisms

Raziyeh Salami1, Marziyeh Salami2, Alireza Mafi3

  • 1Department of Clinical Biochemistry, School of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran.

Cell Communication and Signaling : CCS
|January 29, 2022
PubMed

Insights

Circular RNAs (circRNAs) show potential as therapeutic targets for glioblastoma multiforme (GBM), a deadly brain cancer. This study explores how circRNAs influence GBM development and resistance to therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Glioblastoma multiforme (GBM) is an aggressive, often incurable brain cancer with poor patient survival rates.
  • Therapeutic resistance in GBM stems from cellular heterogeneity and genetic alterations affecting critical cellular processes.
  • Novel therapeutic strategies, including combination therapies, are urgently needed to combat GBM.

Purpose of the Study:

  • To investigate the molecular and cellular mechanisms of circular RNAs (circRNAs) in glioblastoma pathogenesis.
  • To understand the role of circRNAs in regulating GBM development, proliferation, apoptosis, invasion, and chemoresistance.
  • To explore circRNAs as potential therapeutic targets for GBM treatment.

Main Methods:

  • Review and analysis of current literature on circRNAs and GBM.
  • Discussion of signaling pathways (PI3K/Akt/mTOR, Wnt/β-catenin, MAPK) involved in circRNA-mediated GBM pathophysiology.
  • Examination of circRNAs' roles in angiogenesis and metastasis in GBM.

Main Results:

  • Circular RNAs (circRNAs) can act as either tumor suppressors or oncogenes in glioblastoma.
  • circRNAs are implicated in regulating key cancer processes including cell proliferation, apoptosis, invasion, and chemoresistance.
  • Specific signaling pathways and metastatic processes are influenced by circRNAs in GBM.

Conclusions:

  • circRNAs represent promising therapeutic targets for overcoming glioblastoma resistance.
  • Understanding circRNA mechanisms provides insights into GBM pathophysiology.
  • Targeting circRNAs may offer novel strategies for improving GBM patient outcomes.
Keywords:
Circular RNADiagnosisGlioblastoma multiformeSignaling pathwaysTreatment

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