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PCL-PEG copolymer based injectable thermosensitive hydrogels.

Mithun Rajendra Dethe1, Prabakaran A1, Hafiz Ahmed1

  • 1Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Guwahati 781101, India.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|January 29, 2022
PubMed
Summary

Injectable hydrogels made from poly (ε-caprolactone) and polyethylene glycol (PCL-PEG) copolymers offer promising solutions for tissue engineering and drug delivery. Their temperature-sensitive properties enable controlled gelation and swelling for advanced biomedical applications.

Keywords:
Injectable hydrogelPCL/PEG copolymerScaffoldThermoresponsiveTissue engineering

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Stimuli-responsive hydrogels are vital in biomedical applications due to their biocompatibility and biodegradability.
  • In situ forming hydrogels, particularly thermoresponsive ones, are developed using synthetic and natural polymers for injectable delivery.
  • Poly (ε-caprolactone)-polyethylene glycol (PCL-PEG) copolymers are FDA-approved, amphiphilic smart materials exhibiting rapid, reversible physical gelation.

Purpose of the Study:

  • To review the progress of PCL-PEG-based thermosensitive injectable hydrogels over the last decade.
  • To highlight their applications in tissue engineering and localized drug delivery for various diseases.
  • To critically assess the impact of PCL-PEG molecular weight on hydrogel properties.

Main Methods:

  • Literature review focusing on PCL-PEG copolymer synthesis and characterization.
  • Analysis of studies investigating thermoresponsive gelation behavior of PCL-PEG hydrogels.
  • Evaluation of PCL-PEG hydrogels in tissue engineering and drug delivery models.

Main Results:

  • PCL-PEG copolymers demonstrate tunable thermoresponsive gelation, crucial for injectable applications.
  • The chemical structure of PCL-PEG significantly influences solubility, gelation, drug release, and degradation rates.
  • Molecular weight of PCL-PEG is a critical factor in optimizing hydrogel properties for specific biomedical uses.

Conclusions:

  • PCL-PEG-based thermosensitive injectable hydrogels represent a significant advancement in localized drug delivery and tissue engineering.
  • Optimizing copolymer molecular weight is essential for tailoring hydrogel performance in pharmaceutical and biomedical applications.
  • Further research into PCL-PEG hydrogels will likely lead to novel therapeutic strategies and improved patient outcomes.