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Updated: Oct 5, 2025
Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
Published on: May 31, 2016
The association between serum soluble klotho levels and abdominal aorta calcification in older adults
1Laredo Medical Center-Medicine, 1700 E Saunders St, Laredo, TX, 78041, USA. corces07@yahoo.com.
Background:
The mutation of the mouse klotho gene leads to a syndrome resembling aging including calcification of the aorta.
Objective:
To examine the relationship between serum soluble klotho levels and abdominal aorta calcification (AAC) in subjects aged 60-79 years.
Methods:
The National Health and Nutrition Examination Survey data were analyzed using logistic regression models to examine the independent association between soluble klotho tertile levels and the Kauppila AAC-24 score.
Results:
A total of 1042 participants with a median klotho level of 796 pg/ml comprised the study sample. Overall, the prevalence of AAC was 39.2% and severe AAC was seen in 15.6% subjects. Participants with klotho levels ≤ 700 pg/ml were twice as likely (OR 2.21 (95% CI 1.15-4.26) to have severe AAC than their counterparts with klotho levels ≥ 906 pg/ml.
Conclusions:
Soluble klotho levels were inversely associated with severe AAC in older adults.
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