Plug-and-play advanced magnetic resonance spectroscopy
Dinesh K Deelchand1, Pierre-Gilles Henry1, James M Joers1
1Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.
Magnetic Resonance in Medicine
|January 29, 2022
Summary
An automated advanced Magnetic Resonance Spectroscopy (MRS) protocol at 3 Tesla (3T) was developed to streamline high-quality spectroscopic data acquisition. This automated protocol enhances data consistency and success rates, eliminating the need for local MRS expertise.
Area of Science:
- Medical Imaging
- Neuroimaging
- Spectroscopy
Background:
- Advanced Magnetic Resonance Spectroscopy (MRS) protocols offer superior data quality and reproducibility compared to standard vendor protocols.
- However, integrating these advanced MRS protocols into clinical workflows is challenging and necessitates specialized local expertise.
- This limits the widespread adoption of advanced MRS techniques in clinical settings.
Purpose of the Study:
- To develop an automated advanced MRS acquisition protocol for 3 Tesla (3T) MRI scanners.
- To facilitate the acquisition of high-quality spectroscopic data without requiring local MRS expertise.
- To improve the clinical utility and accessibility of advanced MRS.
Main Methods:
- A multi-iteration FAST(EST)MAP protocol was selected for automated B0 shimming by comparing its performance against two vendor protocols.
- Voxel-based B0 and B1 calibrations were integrated into the semi-LASER sequence, coupled with an automated region of interest (VOI) prescription tool.
- The efficiency of the automated protocol was evaluated by comparing calibration time and usable dataset fraction against a manually executed non-automated protocol in a clinical cohort.
Main Results:
- The automated FAST(EST)MAP protocol demonstrated significantly narrower water linewidths compared to vendor B0 shim protocols across six brain locations (p < 1e-5).
- Automated B0 and B1 calibrations reduced acquisition time by approximately 4.5 minutes per voxel compared to manual execution.
- All spectra acquired using the automated protocol were usable, contrasting with 86% usability for the manual protocol, and exhibited greater spectral quality consistency.
Conclusions:
- The developed "plug-and-play" advanced MRS protocol enables automated, high-quality MRS data acquisition.
- The protocol achieves a high success rate and consistency on a clinical 3T platform.
- This automation significantly lowers the barrier for clinical implementation of advanced MRS techniques.
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