Bovine RPE heterotransplants simulate proliferative vitreoretinopathy (PVR) in rabbits

A model of proliferative vitreoretinopathy (PVR) is described. This is the first reported model based on the transplantation of heterologous retinal pigment epithelium cells into the vitreous cavity of rabbits. Freshly isolated cells or short-term primary cultures of bovine pigment epithelium are employed. Strands develop in the vitreous cavity and, with a frequency now approaching 100%, traction retinal detachments develop by 3-4 weeks. Light and electron microscopic features of this model parallel those found for transplanted autologous RPE cells; there are no overt signs of rejection. Examination of the strands should prove useful in identifying strategies of therapeutic value. This model permits such studies, since retinal detachments in adequate numbers are readily produced. The model resembles human PVR.