Intranasal administration of beta-interferon in rabbits

beta-Interferon (IFN) administered intranasally in solution or as a powder without surfactants was not absorbed in rabbits. However, absorption occurred after the addition of surfactants (non-ionic, anionic and amphoteric). Maximum concentrations of IFN in plasma were dependent on the surfactant used, sodium glycocholate being the most effective. Total absorption of IFN following nasal administration with sodium glycocholate was 2.2% of that following intravenous administration.