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Updated: Oct 5, 2025

Characterization of Molecular Mechanisms of In vivo UVR Induced Cataract
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Marijuana smoking and cataract.

S Lehrer1, P H Rheinstein2

  • 1Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, United States.

Journal Francais D'Ophtalmologie
|January 30, 2022
PubMed
Summary
This summary is machine-generated.

Cannabis use was linked to developing cataracts at a younger age, independent of cigarette smoking. However, cannabis use did not significantly increase cataract risk in a large UK Biobank study.

Keywords:
CannabisCataractCataracteGoudronTarToxicityToxicité

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Area of Science:

  • Ophthalmology
  • Toxicology
  • Epidemiology

Background:

  • Cigarette smoking is a known cataract risk factor.
  • Cannabis smoke shares carcinogenic compounds with tobacco smoke.

Purpose of the Study:

  • To investigate the association between cannabis smoking and cataract development.
  • To analyze UK Biobank data for cannabis use and cataract incidence.

Main Methods:

  • Analysis of UK Biobank data including subjects with cataracts and smoking habits.
  • Cataract diagnosis using ICD-10 code H25.
  • Assessment of cannabis and cigarette smoking history.

Main Results:

  • Cannabis users (11-100+ times) developed cataracts 4-5 years younger than non-users.
  • Cannabis use was significantly related to earlier cataract diagnosis (P<0.001), independent of cigarette smoking.
  • Current cigarette smoking showed a significant association with a 1.2 odds ratio for cataract, while cannabis use did not.

Conclusions:

  • The chemical similarity between cannabis and tobacco smoke suggests a potential link to cataract.
  • Further research is warranted to fully understand the relationship between cannabis use and cataract formation.