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Synthesis and antinociceptive activity of dezocine degradation products
M Abou-Gharbia1, J Tokolics, M Freed
1Medicinal Chemistry and Neuropsychopharmacology Sections, Wyeth Laboratories, Philadelphia, PA 19101.
Drug Design and Delivery
|February 1, 1987
Abstract:
Three degradation products of dezocine were synthesized and tested for possible antinociceptive activity. 13-Amino-5,6,7,8,9,10-hexahydro-5-methyl-5,11-methanobenzocyclodecen+ ++-3-ol demonstrated antinociceptive properties comparable to morphine.