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Multivariate statistical analysis of L-dopa esters as potential anti-parkinsonian prodrugs
H Van de Waterbeemd1, B Testa, C Marrel
1School of Pharmacy, University of Lausanne, Switzerland.
Drug Design and Delivery
|December 1, 1987
Abstract:
This paper reports a QSAR study of thirteen L-DOPA esters previously synthesised and examined for their physicochemical, biochemical and behavioural properties. Multivariate statistical analysis (principal component analysis, cluster analysis, simple and multiple linear regression) reveals favourable and unfavourable structural features of L-DOPA prodrugs. Some of the many biochemical and behavioural activities investigated are shown to be redundant. These indications may contribute to the design of novel L-DOPA prodrugs.