Primary Central Nervous System Lymphoma with Bone and Subcutaneous Tissue Invasion

Primary central nervous system lymphoma is a rare form of extranodal non-Hodgkin lymphoma. Few cases of primary central nervous system lymphoma involving bone and subcutaneous tissue invasion have been reported. Herein, we present the case of a 45-year-old man who experienced paroxysmal throbbing pain in the occipital area for more than 1 year, followed by progressive dysarthria and dyspnea for more than 4 days. Craniotomy and tumor removal were performed. Operative findings showed a posterior occipital soft tumor whose cells had invaded the skull and subcutaneous tissue.