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Updated: Oct 5, 2025

Generation, High-Throughput Screening, and Biobanking of Human-Induced Pluripotent Stem Cell-Derived Cardiac Spheroids
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Generating 3D human cardiac constructs from pluripotent stem cells.

Chang Liu1, Xing Feng1, Guoping Li2

  • 1Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong 226011, China; Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Life Science, Shanghai University, Shanghai 200444, China.

Ebiomedicine
|January 30, 2022
PubMed
Summary
This summary is machine-generated.

Human pluripotent stem cell-derived cardiomyocytes offer powerful in vitro models for studying heart diseases and testing drugs. Recent advancements focus on 3D culture systems, though challenges remain for deeper research.

Keywords:
Cardiac 3D constructsCardiac organoidEngineered heart tissueHeart-on-chipMicrotissuePluripotent stem cellsSpheroids

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Area of Science:

  • Stem Cell Biology
  • Cardiovascular Research
  • Disease Modeling

Background:

  • Human pluripotent stem cells (hPSCs) provide extensive opportunities for in vitro disease modeling.
  • hPSC-derived cardiomyocytes (hPSC-CMs) are valuable tools for cardiac disease research, drug screening, and mechanism studies.

Purpose of the Study:

  • To review the advantages and limitations of 2D hPSC-CM systems.
  • To introduce recent developments in 3D culture platforms using hPSCs for cardiac research.

Main Methods:

  • Review of existing literature on 2D and 3D hPSC-CM culture systems.
  • Discussion of bioengineering advancements in 3D platform construction.

Main Results:

  • 2D hPSC-CM systems offer established but limited approaches for cardiac modeling.
  • Emerging 3D hPSC-derived culture platforms show promise for more complex cardiac disease modeling.

Conclusions:

  • While 3D culture technologies have advanced, challenges persist in optimizing these platforms for comprehensive cardiac research.
  • Further development is needed to fully leverage 3D hPSC-derived models for in-depth study of cardiovascular diseases.