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Updated: Oct 5, 2025

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients

Published on: March 1, 2024

Chronic mucocutaneous candidiasis.

Bernadett Hon-Balla^1,2, Melinda Erdős^3,4

¹1 Semmelweis Egyetem, Általános Orvostudományi Kar, Bőr-, Nemikórtani és Bőronkológiai Klinika Budapest Magyarország.

|January 30, 2022

Summary

This summary is machine-generated.

Chronic mucocutaneous candidiasis involves persistent Candida infections due to Th17 immune defects. Genetic testing aids diagnosis and prenatal screening for this heterogeneous disorder.

Keywords:

Candida Th17-cell Th17-sejt chronic mucocutaneous candidiasis krónikus mucocutan candidiasis

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Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice

Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice

Published on: February 18, 2015

Area of Science:

Immunology
Genetics
Dermatology

Background:

Chronic mucocutaneous candidiasis (CMC) is a group of genetically diverse disorders.
Characterized by persistent, non-invasive Candida infections of skin, nails, and mucous membranes.
Underlying cause is a Th17-cell mediated immune defect, often due to gene mutations.

Purpose of the Study:

To present the main types of CMC.
To explore clinical aspects, diagnostic methods, and therapies.
To summarize the molecular genetic background and pathomechanism.

Main Methods:

Review of existing literature on CMC.
Analysis of clinical presentations.
Genetic testing for diagnosis and family screening.

Main Results:

CMC presents as isolated or syndromic forms.
Syndromic forms include autoimmune disorders, commonly affecting the endocrine system.
Genetic testing is crucial for diagnosis and enables prenatal testing.

Conclusions:

Understanding the genetic basis and pathomechanism of CMC is essential.
Accurate diagnosis through genetic testing facilitates appropriate management.
Further research into molecular genetics can improve therapeutic strategies.