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Tocopherol in Osteoarthritis: a controlled pilot study.

I Machtey, L Ouaknine

    Journal of the American Geriatrics Society
    |July 1, 1978
    PubMed
    Summary
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    Tocopherol, a form of vitamin E, demonstrated significant analgesic effects in osteoarthritis patients. This vitamin E supplement showed a notable improvement in pain relief compared to placebo treatments.

    Area of Science:

    • Rheumatology
    • Nutritional Science
    • Pharmacology

    Background:

    • Osteoarthritis (OA) is a degenerative joint disease causing pain and disability.
    • Current treatments for OA have limitations and side effects.
    • Tocopherol (vitamin E) has antioxidant properties that may influence inflammatory processes in OA.

    Purpose of the Study:

    • To evaluate the analgesic efficacy of tocopherol in patients with osteoarthritis.
    • To compare the effects of tocopherol with a placebo in managing OA symptoms.

    Main Methods:

    • A simple-blind, cross-over study design was employed.
    • Thirty-two patients with osteoarthritis were enrolled; 29 completed the study.
    • Patients received either tocopherol (600 mg/day) or placebo for 10 days, then switched treatments.

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  • Efficacy was assessed via patient records, physician interviews, and use of rescue analgesics.

    • Main Results:

    • A significant analgesic effect was reported by 52% of patients receiving tocopherol.
    • Only 4% of patients receiving placebo reported a similar analgesic effect.
    • The difference in reported pain relief between tocopherol and placebo was statistically significant.

    Conclusions:

    • Tocopherol exhibits a significant analgesic effect in osteoarthritis patients.
    • Further large-scale studies are warranted to confirm these findings and explore tocopherol's role in OA management.