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Single-throughput Complementary High-resolution Analytical Techniques for Characterizing Complex Natural Organic Matter Mixtures

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Knowledge-Driven Approaches to Create the MTox700+ Metabolite Panel for Predicting Toxicity.

Elena Sostare¹, Thomas N Lawson¹, Lucy R Saunders²

¹Michabo Health Science, University of Birmingham Enterprise, Birmingham Research Park, Birmingham B15 2SQ, UK.

Toxicological Sciences : an Official Journal of the Society of Toxicology

|January 30, 2022

Summary

A new metabolic biomarker panel (MTox700+) was created to improve toxicological assessments. This resource aids in predicting chemical effects and adverse outcomes, enhancing hazard evaluation.

Keywords:

adverse outcome biomarker metabolite metabolomics molecular pathway systematic review

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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

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Published on: November 29, 2024

Area of Science:

Toxicology
Metabolomics
Biomarker Discovery

Background:

Metabolite levels reflect molecular phenotypes downstream of chemical exposure, crucial for predicting toxicity.
Current toxicological biomarker resources are fragmented, hindering comprehensive chemical hazard assessment.
A standardized metabolic biomarker panel is needed, analogous to the S1500+ gene panel for transcriptomics.

Purpose of the Study:

To establish a publicly available metabolic biomarker panel for toxicology (MTox700+).
To enable prediction of pathway perturbations and adverse outcomes from chemical exposures.
To create a foundational resource for molecular mechanistic data in chemical safety evaluation.

Main Methods:

Systematic review of toxicological resources, including assays, databases, and literature.
Evidence mapping to consolidate proposed metabolic biomarkers.
Comparison with the S1500+ gene biomarker panel.

Main Results:

A panel of 722 metabolic biomarkers for toxicology (MTox700+) was generated.
64% of MTox700+ biomarkers are linked to molecular pathways, and 80% to adverse outcomes.
Reference standards and assays are available for a high percentage of the identified biomarkers.

Conclusions:

The MTox700+ panel provides a comprehensive resource for toxicological research.
This panel facilitates the prediction of chemical toxicity and mode of action.
Future laboratory deployment of MTox700+ will support robust chemical hazard assessment.