Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alveolar Bone Regeneration: Smart Biomaterials and Physical Stimulation.

Journal of biomedical materials research. Part B, Applied biomaterials·2026
Same author

PRMT5 inhibition impairs Fanconi Anemia pathway-mediated homologous recombination and enhances the antitumor efficacy of Temozolomide in glioblastoma.

Cell death & disease·2026
Same author

Jagged ligand expression by alpha-SMA progenitors is required for normal fracture healing.

Bone·2026
Same author

Facial nerve pathology: emerging strategies for regeneration and functional restoration.

Journal of materials chemistry. B·2025
Same author

Scar-reducing ionically conductive chitosan bandage: Combining ionic and electrical stimulation for optimal wound healing.

Biomaterials·2025
Same author

Effects of aging on the immune and periosteal response to fracture injury.

Bone·2025

Related Experiment Video

Updated: Oct 5, 2025

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
09:32

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

10.0K

Natural Polymer-Based Micronanostructured Scaffolds for Bone Tissue Engineering.

Sara Katebifar1,2, Devina Jaiswal3, Michael R Arul2

  • 1Department of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.

Methods in Molecular Biology (Clifton, N.J.)
|January 30, 2022
PubMed
Summary
This summary is machine-generated.

This study introduces novel micronanostructured scaffolds made from cellulose acetate and collagen for bone tissue engineering. These scaffolds promote osteoprogenitor cell activity, offering a promising alternative to traditional bone grafts.

Keywords:
BoneCelluloseCollagenMesenchymal Stem CellsMicronanostructuresNanofibersNatural PolymersRegenerative MedicineScaffoldsTissue Engineering

More Related Videos

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

9.8K
Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion
07:14

Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion

Published on: May 10, 2020

4.2K

Related Experiment Videos

Last Updated: Oct 5, 2025

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
09:32

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

10.0K
Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

9.8K
Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion
07:14

Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion

Published on: May 10, 2020

4.2K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Traditional bone grafts (allografts, autografts) face limitations like availability and immune response.
  • Tissue-engineered implants offer an alternative, with various fabrication techniques explored for scaffold creation.
  • Natural polymers like polysaccharides and collagen are biocompatible but often require cross-linking for stability.

Purpose of the Study:

  • To develop mechanically stable and bioactive micronanostructured scaffolds for bone tissue engineering.
  • To combine cellulose derivatives and collagen for enhanced bone regeneration properties.
  • To provide a detailed protocol for creating and characterizing these novel scaffolds.

Main Methods:

  • Utilizing solvent-sintered cellulose acetate (CA) microspheres to create a trabecular bone-like microstructure.
  • Imbuing collagen nanostructures into the CA scaffold via molecular self-assembly.
  • Characterizing the resultant CA-collagen micronanostructures for bone tissue engineering applications.

Main Results:

  • The CA-collagen micronanostructures exhibit improved osteoprogenitor cell adhesion, proliferation, migration, and differentiation.
  • Enhanced extracellular matrix (ECM) secretion was observed, promoting bone healing.
  • The scaffolds demonstrate potential as an alternative material platform to FDA-approved polyesters.

Conclusions:

  • Micronanostructured CA-collagen scaffolds are a viable alternative to traditional bone grafts.
  • These scaffolds effectively support osteoprogenitor cell functions crucial for bone regeneration.
  • The developed material platform shows significant promise for bone tissue engineering applications.