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Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
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Antiplatelet Use in Ischemic Stroke.

Marharyta Kamarova1, Sheharyar Baig1,2, Hamish Patel1

  • 1Department of Clinical Neurology, Royal Hallamshire Hospital, Sheffield, UK.

The Annals of Pharmacotherapy
|January 31, 2022
PubMed
Summary
This summary is machine-generated.

Aspirin and clopidogrel are effective for secondary stroke prevention, but dual therapy poses higher bleeding risks. Personalized antiplatelet therapy, considering genetics and diversity, is key for future stroke prevention.

Keywords:
antiplateletsaspirincilostazolclopidogrelprasugrelstroketicagrelorticlopidine

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Area of Science:

  • Neurology
  • Pharmacology
  • Cardiovascular Medicine

Background:

  • Antiplatelet agents are crucial for preventing ischemic stroke recurrence.
  • Evidence for optimal agent selection and duration remains evolving.

Purpose of the Study:

  • To review antiplatelet agents for primary and secondary stroke prevention.
  • To analyze efficacy, cost, and limitations of various antiplatelet medications.

Main Methods:

  • Comprehensive literature search of MEDLINE, Cochrane Reviews, and PubMed (1980-2021).
  • Inclusion of original articles, reviews, and scientific meeting abstracts.
  • Independent evaluation of English-language articles and international guidelines.

Main Results:

  • Aspirin and clopidogrel show strong evidence for secondary stroke prevention.
  • Dual antiplatelet therapy is effective acutely but increases hemorrhage risk long-term.
  • Treatment failure can stem from poor adherence and genetic factors; cilostazol may offer benefits in specific populations.

Conclusions:

  • While established agents exist, personalized antiplatelet therapy is a significant area for future research.
  • Investigating platelet polymorphisms and conducting trials with diverse populations are crucial next steps.