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Anti-inflammatory strategies for atherosclerotic artery disease

Federica Agnello1, Davide Capodanno1

  • 1Division of Cardiology, A.O.U. Policlinico "G. Rodolico-San Marco" University of Catania, Catania, Italy.

Expert Opinion on Drug Safety
|January 31, 2022
PubMed

Insights

Targeting inflammation in atherosclerosis, the cause of coronary artery disease (CAD), is a promising therapeutic strategy. Colchicine shows potential as a safe anti-inflammatory agent for cardiovascular prevention due to recent positive trial results.

Area of Science:

  • Cardiovascular Research
  • Immunology
  • Pharmacology

Background:

  • Atherosclerosis, a primary cause of coronary artery disease (CAD), is significantly driven by inflammation.
  • Targeting inflammation offers a novel therapeutic avenue beyond traditional cardiovascular risk factor management.
  • Research is actively exploring the efficacy and safety of both existing and new anti-inflammatory drugs for cardiovascular health.

Purpose of the Study:

  • To review current strategies for mitigating the inflammatory burden in atherosclerosis.
  • To assess the progress and challenges in developing specific anti-inflammatory drugs for cardiovascular prevention.
  • To evaluate the potential of drugs targeting the NLRP3-IL1-IL6-hsCRP pathway, including colchicine.

Main Methods:

  • Review of multimodal immune response activation in atherosclerosis.
  • Analysis of clinical trial data for anti-inflammatory drugs.
  • Investigation of drugs targeting the NLRP3-IL1-IL6-hsCRP pathway, including colchicine.

Main Results:

  • Development of several specific anti-inflammatory drugs has been discontinued due to lack of efficacy.
  • Ongoing trials are evaluating drugs targeting the NLRP3-IL1-IL6-hsCRP pathway.
  • Colchicine, an existing immune disorder drug, is under investigation for cardiovascular benefits.

Conclusions:

  • A significant challenge with specific anti-inflammatory drugs is the risk of immunological suppression.
  • Colchicine demonstrates a favorable safety profile and positive results in recent randomized trials.
  • Colchicine is anticipated to become increasingly recognized as an anti-inflammatory agent for cardiovascular prevention.
Abstract

Keywords:
AtherosclerosisNLRP3-IL1-IL6-hsCRPcolchicinecoronary artery diseaseimmune systeminflammation

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