Effects of delay to stroke unit admission in patients with ischemic and hemorrhagic stroke

Bing Yu Chen1, Himanshu Gupta1, Clifford Yacas2

  • 1Division of Neurology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

Insights

Delays in transferring acute stroke patients to a central stroke unit are linked to longer hospital stays and worse functional outcomes. Optimizing transfer protocols is crucial for improving stroke patient care and recovery.

Area of Science:

  • Neurology
  • Public Health
  • Healthcare Management

Background:

  • Timely transfer to specialized stroke units is critical for optimal acute stroke patient management.
  • Peripheral institutions often transfer patients to comprehensive stroke centers (CSCs) for advanced care.

Purpose of the Study:

  • To investigate the association between delayed transfer to a central stroke unit and patient outcomes.
  • To identify factors contributing to transfer delays in acute stroke care.

Main Methods:

  • Retrospective cohort study of 1435 acute stroke patients admitted to a CSC from three emergency departments (EDs) between 2016-2018.
  • Primary outcomes included length of stay, functional status at 3 months, discharge destination, and time to stroke investigations.
  • Analysis examined the impact of transfer delays on these outcomes and identified contributing factors.

Main Results:

  • Each day of transfer delay correlated with a 2.0-day increase in length of stay and an 11.5-hour delay in vascular imaging.
  • Delays were associated with reduced odds of nondisabled functional status at 3 months (OR 0.98).
  • Factors influencing delay included stroke onset timing, brain imaging, admission service, and transfer from a primary stroke center (PSC).

Conclusions:

  • Transfer delays from PSCs to a CSC negatively impact hospital stay duration and functional outcomes for acute stroke patients.
  • Streamlining inter-facility transfer processes is essential for improving stroke care delivery and patient prognosis.
Abstract

Related Concept Videos

Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...