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Microfluidics device for drug discovery, screening and delivery
Rupesh Maurya1, Nisarg Gohil1, Gargi Bhattacharjee1
1Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, Gujarat, India.
Progress in Molecular Biology and Translational Science
|January 31, 2022
Summary
Microfluidics and lab-on-chip technologies enable precise drug discovery and delivery using minimal reagents. These platforms offer programmable control for optimizing drug characteristics and high-throughput screening in various scientific fields.
Area of Science:
- Biotechnology
- Nanotechnology
- Drug Development
Background:
- Microfluidics and lab-on-chip are advanced technologies.
- They are utilized in drug discovery, screening, and delivery.
- These platforms handle sample preparation, culturing, incubation, and screening via multi-channels.
Purpose of the Study:
- To highlight the capabilities of microfluidics and lab-on-chip technologies.
- To showcase their application in optimizing drug characteristics.
- To explore their potential in advanced diagnostic and therapeutic applications.
Main Methods:
- Utilizing micro- to nanolitre volumes of reagents.
- Employing programmable operations for precise control over flow rate.
- Leveraging droplet reactors for fluid mixing and particle synthesis.
Main Results:
- Demonstrated high-throughput performance in various assays.
- Enabled fine-tuning of drug size, shape, and composition.
- Facilitated encapsulation of biological entities for drug delivery.
Conclusions:
- Microfluidics platforms offer significant advantages for drug research.
- These technologies are versatile, applicable across chemistry, biomedical, biology, and nanotechnology.
- There is substantial scope for advancing diagnostic and therapeutic applications using microfluidics.
