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Regenerative effect of expired platelet concentrates in human therapy: An update

Thierry Burnouf1, Hadi Alphonse Goubran2

  • 1Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan.

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|January 31, 2022
PubMed

There is concrete evidence that outdated allogeneic platelet concentrates not used for transfusion are valuable sources of functional trophic factors, including growth factors, cytokines, chemokines, anti-inflammatory and antioxidant molecules. Such outdated platelet concentrates can be used to produce human platelet lysates (HPL), a proven potent growth supplement for the propagation of therapeutic human cells, including mesenchymal stromal cells. On-going preclinical studies demonstrate the interest in such "outdated" allogeneic platelet lysates for treating corneal diseases and neurological disorders of the central nervous system, potentially opening vital therapeutic perspectives.

Keywords:
Cell therapyNeurologyPlatelet lysatePlateletsRegenerative medicineStem cells

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