Prognostic Value of the Pattern of Non-Adherence to Anti-Platelet Regimen in Stented Patients (PARIS) Bleeding Risk...

Area of Science:

• Cardiology
• Clinical Research
• Outcomes Research

Background:

• The Patterns of non-Adherence to Anti-Platelet Regimen in Stented Patients (PARIS) bleeding risk score is used to predict bleeding after percutaneous coronary intervention (PCI).
• The prognostic value of the PARIS score for long-term mortality and heart failure hospitalization post-PCI remains unevaluated.

Purpose of the Study:

• To assess the prognostic capability of the PARIS bleeding risk score for predicting all-cause mortality, cardiac mortality, and heart failure hospitalization in patients following PCI.

Main Methods:

• A prospective study involving 1061 consecutive patients undergoing PCI.
• Patients were stratified into low, intermediate, and high-risk groups based on the PARIS score.
• Outcomes including all-cause mortality, cardiac mortality, and heart failure hospitalization were tracked.

Main Results:

• Kaplan-Meier analysis showed the highest rates of all-cause mortality, cardiac mortality, and heart failure hospitalization in the high-risk PARIS score group (P < 0.001 for all).
• Multivariable Cox analysis indicated that intermediate and high-risk groups had significantly higher all-cause mortality compared to the low-risk group (aHR 6.06, P=0.013 and aHR 12.50, P<0.001, respectively).

Conclusions:

• The PARIS bleeding risk score is a significant predictor of all-cause mortality in patients after PCI.
• The PARIS score demonstrates prognostic value beyond bleeding risk, extending to overall survival in stented patients.