Exercise Capacity and Frailty Are Associated with Cerebral White Matter Hyperintensity in Older Adults with...

Cerebral white matter hyperintensity (WMH) is highly prevalent among older adults. There is little information about the relationship among WMH extent, frailty status, and exercise capacity in older adults with cardiovascular disease (CVD). We assessed the association of WMH with frailty and exercise capacity in CVD patients.Seventy-eight stable older adults with CVD were evaluated for WMH, the Kihon Checklist (KCL), short physical performance battery score (SPPB), and cardiopulmonary exercise testing. WMH volume was quantified on brain magnetic resonance imaging. Patients were classified into 3 groups (using tertiles of 0.52% and 1.05%) according to WMH as a percentage of intracranial volume (ICV), and their KCL scores and exercise capacities were compared. The 3 WMH/ICV groups were mild (n = 26, 0.26% ± 0.14% of intracranial volume), moderate (n = 26, 0.70% ± 0.15%), and severe (n = 26, 1.75% ± 0.67%). Peak VO₂ was 15.2 ± 3.7 mL kg^-1 minute^-1 (mild group), 12.9 ± 3.5 mL kg^-1 min^-1 (moderate), and 11.4 ± 2.3 mL kg^-1 minute^-1 (severe) (mild versus moderate, P = 0.049; mild versus severe, P = 0.001). Multivariate regression analysis showed significant associations of severe WMH/ICV with peak VO₂ and SPPB. Cerebral WMH was strongly negatively associated with SPPB and peak VO₂. WMH volume may be related to exercise capacity and frailty in stable older adult patients with CVD.