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Updated: Oct 5, 2025
Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice
Published on: September 30, 2021
Acquired hemophilia A (AHA): underreported, underdiagnosed, undertreated medical condition
Doaa M El Demerdash1, Alia Ayad1, Noha Tawfik1
1Internal Medicine Department, Kasr Al-Ainy Hospital, Faculty of Medicine, Cairo University, Cairo, Egypt.
Background:
Acquired hemophilia A (AHA) is a rare acquired bleeding disorder occurred due to the formation of inhibitory antibodies neutralizing endogenous factor VIII.
Main Body:
About half the cases are idiopathic. Symptoms include severe and unexpected bleeding that could be life-threatening. High index of suspicion should be raised when unexplained subcutaneous or post-surgical bleeding with isolated prolonged APTT.
Conclusions:
Acquired hemophilia A is a rare underdiagnosed underreported acquired hemostatic disorder that presents with sudden usually life-threatening bleeding; it is crucial to raise awareness and suspicion index of clinicians for early diagnosis and treatment to avoid morbidity and mortality.
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